CCSVI - Latest Research News

If CCSVI is not associated with MS or is not considered to be a causative agent of MS it is reasonable to consider that it is a stand-alone disorder that would affect an MS sufferer’s health and perhaps exacerbate their symptoms. Therefore as with other stand-alone disorders such as; Candida, Coeliac, Leaky Gut, Anaemia; which an MS person may experience and which may exacerbate their symptoms it would be reasonable to suggest that all MS sufferers are investigated and as with other underlying disorders, if CCSVI is uncovered the person should be offered the liberation treatment in an attempt to alleviate their suffering. Neurologists are willing to prescribe disease modifying drugs which have severe adverse side effects, therefore why should the Liberation procedure be viewed differently?

Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency.

Baracchini C, Perini P, Causin F, Calabrese M, Rinaldi F, Gallo P.

Source - From the First Neurology Clinic (C.B., P.P., M.C., F.R., P.G.), Multiple Sclerosis Centre of The Veneto Region (P.P., M.C., F.R., P.G.), and Neuroradiology Unit (F.C.), Department of Neurosciences, University Hospital, Padova, Italy.

Abstract

OBJECTIVE:

Chronic cerebrospinal venous insufficiency (CCSVI) had been suggested to play a major pathogenetic role in multiple sclerosis (MS), but recent data on early stages of MS have not confirmed this theory. Nonetheless, CCSVI could represent a late phenomenon of MS or be associated with progression of disability. Thus, we studied CCSVI prevalence in primary progressive (PP) and secondary progressive (SP) MS, to clarify whether CCSVI characterizes the progressive forms of this disease.

METHODS:

A total of 35 patients with SPMS, 25 patients with PPMS, and 60 age- and gender-matched normal controls (NC) were enrolled into a cross-sectional study. Extracranial and transcranial high-resolution venous echo color Doppler sonography (ECDS-TCDS) was performed in all patients and NC. Those patients having any abnormal ultrasound finding were asked to undergo selective venography (VGF).

RESULTS:

Patients with PPMS (11 women, 14 men; mean age 47 ± 11 years) had a disease duration of 11 ± 7 years and Expanded Disability Status Scale (EDSS) score of 6.0 ± 0.5. Patients with SPMS (22 women, 13 men; mean age 45 ± 14.5 years) had a disease duration of 18 ± 14 years and EDSS score of 6.0 ± 0.8. TCDS was normal in all patients. ECDS showed one or more abnormal findings in 9/60 (15.0%) patients (7/35 [20.0%] SPMS, 2/25 [8.0%] PPMS) and in 14/60 (23.3%) NC (p not significant for all comparisons). CCSVI criteria were fulfilled in 0 NC and 4 (6.7%) patients with MS: 3 SPMS and 1 PPMS. VGF, performed in 6/9 patients, was abnormal only in one case who had bilateral internal jugular vein stenosis.

CONCLUSION:

Our findings indicate that CCSVI is not a late secondary phenomenon of MS and is not associated with disability.